Journal: European Journal of Drug Metabolism and Pharmacokinetics
Article Title: The effect of sunitinib on the plasma exposure of intravenous paracetamol and its major metabolite: paracetamol glucuronide
doi: 10.1007/s13318-014-0191-z
Figure Lengend Snippet: A log scale plot of arithmetic mean sunitinib (SUN) and metabolite (SU12662) plasma concentration versus time following oral administration of a single 25 mg dose of sunitinib in rabbits
Article Snippet: Sunitinib and SU12662 were purchased from LGC Standards (Lomianki, Poland), HPLC grade acetonitrile, paracetamol and paracetamol glucuronide, perchloric acid, theophyllinum, from Sigma-Aldrich (Poland), 85 % orthophosphoric acid, 2 M sodium hydroxide and methanol from Merck (Poland), sodium sulphate anhydrous from Fluka (Poland).
Techniques: Concentration Assay